News

All Supplements Are Not Created Equal

TO TAKE OR NOT TO TAKE?..., THAT IS THE QUESTION

Food supplements were invented because people’s well being left something to be desired. Our bodies have only the resources we consume from which to take materials to generate and maintain our cells. The difference between nutrient-depleted food and nutrient-rich fresh grains, fruits and vegetables can be the difference between being vitally healthy, or desperately ill. Modern farming practices and food processing are rapidly depleting the raw materials and biological life in the food chain and the toll it is taking can be counted in the statistics of illness and death. In a world where modern agriculture thinks it makes sense to grow food in deficient soil, bathed in pesticides and herbicides, picking produce green to be gas-aged in storage to create the illusion of being ripe, irradiating any sign of life left, supplements provide a much needed resource.

Vitalica™: Induces Phase II Enzymes in a Double Blind Crossover Study using a Single Dose of 500mgs of Sulforaphane Glucosinolate 10%.

June 30, 2008
 
This study was conducted at the University of Illinois School of Medicine in conjunction with the College of Food Science & Human Nutrition. Under the direction of Dr. Elizabeth Jeffery-Professor of Toxicology.

Conclusions and Excerpts from the Pre Publication Clinical Trial are as follows:

1. ”......see the enclosed graph, and notice that the appearance of BroccoRaphanin™ (the active ingredient in Vitalica™) metabolites in the urine of those receiving BroccoRaphanin™ alone was significantly increased over control values, showing bioavailability of sulforaphane from BroccoRaphanin™ in human subjects.”

2. “The importance of these findings is that BroccoRaphanin™ contains no myrosinase enzyme, providing stability and shelf life to the product, something that fresh vegetables do not have.”

3. “Yet BroccoRaphanin is still able to form active sulforaphane. This is because the gut microflora is able to hydrolyze BroccoRaphanin (the active ingredient in Vitalica™).”

4. BroccoRaphanin™ (the active ingredient in Vitalica™) in a 1:1 mix meal was hydrolyzed exponentially when consumed with fresh vegetables in a meal mix that contains the active enzyme myrosinase. This suggests that the addition of BroccoRaphanin™ (the active ingredient in Vitalica™) provided substantially more sulforaphane than a meal mix alone.

5. “Importantly, we saw several (GST) glutathione S-transferases up regulated ............. Following ingestion of BroccoRaphanin™.......”

6. .......these results show clearly that BroccoRaphanin™ (the active ingredient in Vitalica™) was converted to sulforaphane, which was absorbed and caused increases in phase II detoxification enzymes.

7. The up regulation of several GST (glutathione S-transferases) is extremely important for several reasons:

A. The glutathione S-transferase (GST) family of enzymes comprises a long list of cytosolic, mitochondrial, and microsomal proteins that are capable of multiple reactions with a multitude of substrates, both endogenous and xenobiotic. This is a member of MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism)

B. The first enzymatic step in mercapturic acid formation.

C. Glutathione S-transferases are considered, among several others, to contribute to the phase II biotransformation of xenobiotics. This activity is useful in the detoxification of endogenous compounds such as peroxidised lipids (Leaver and George, 1998)

D. Conjugates electrophiles and assist with removal from the body.

E. GSTs may also bind toxins and function as transport proteins. Because of this, an early term for GSTs was “ligandin” - Litwack, Gerald., Ketterer, Brian & Arias, Irwin, J. (1971).